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These same pharmacology properties direct receptor activation, reduced binding-protein clearance, and the long half-life explain both the anabolic interest researchers have in IGF-1 LR3 and its primary safety liabilities

Moreover, it was also shown that, as a calcium-binding protein, the Fh8 tag and Fh8-fused proteins can be eluted by using a calcium chelating agent, such as EDTA

[DOI] [PMC free article] [PubMed] [Google Scholar] Brusselle G., Germinaro M., Weiss S., Zangrilli J

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Woods et al., 2016)